Aerosol particle transport and deposition in a CT-based lung airway for helium-oxygen mixture

M. S. Islam, S. C. Saha, P. M. Young

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

2 Citations (Scopus)

Abstract

A precise understanding of the aerosol particle transport and deposition (TD) in the human lung is important to improve the efficiency of the targeted drug delivery, as the current drug delivery device can deliver only a small amount of the drug to the terminal airways. A wide range of available computational and
experimental model has improved the understanding of particle TD in the human lung for air breathing. However, the helium-oxygen gas mixture breathing is less dense than the air breathing and the turbulent dispersion is less likely to develop at the upper airways, which eventually reduce the higher deposition at the upper airways. This study aims to investigate the effects of the
helium-oxygen gas mixture at the upper airways of a realistic human lung. A realistic lung model is developed from the CTScan data for a healthy adult. A Low Reynolds Number (LRN) k-ω model is used to calculate the fluid motion and Lagrangian particle tracking scheme is used for particle transport. ANSYS Fluent solver (19.0) is used for the numerical simulation and MATLAB software is used for the advanced post-processing. The numerical results show that helium-oxygen gas mixture breathing reduces the aerosol deposition at the upper airways than the air breathing. The present simulation along with more case-specific investigation will improve the understanding of the particle TD for the helium-oxygen mixture.
Original languageEnglish
Title of host publicationProceedings of the 21st Australasian Fluid Mechanics Conference
EditorsT. C. W. Lau, R. M. Kelso
Place of PublicationAdelaide
PublisherAustralasian Fluid Mechanics Society
Number of pages4
ISBN (Electronic)9780646597843
Publication statusPublished - 2018
Externally publishedYes
Event21st Australasian Fluid Mechanics Conference, AFMC 2018 - Adelaide, Australia
Duration: 10 Dec 201813 Dec 2018

Conference

Conference21st Australasian Fluid Mechanics Conference, AFMC 2018
CountryAustralia
CityAdelaide
Period10/12/1813/12/18

Keywords

  • Computational fluid dynamics
  • Multiphase and particle-laden flows
  • Turbulence
  • Biomedical fluid mechanics
  • Micro/biofluid mechanics

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