Afferent vagal control of renin release in the anesthetized cat

A. Stella, R. A.L. Dampney, R. Golin, A. Zanchetti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In the anesthetized, moderately fluid-depleted cat (no fluid infusion during the experiment), bilateral cervical vagotomy caused a marked and prompt increase in renin release from the innervated kidney without significantly affecting renin release from the contralateral denervated kidney. This excitatory effect was a transient one, however, and disappeared 15-30 minutes after vagotomy. The renin-releasing action of vagotomy was antagonized by moderate fluid expansion with 2% dextran in saline (6 ml/kg per hr). Reflex renin release from the innervated kidney was also induced by head-up tilting lasting for 10 minutes, and this reflex response was prevented or markedly weakened by previous cervical vagotomy. It is concluded that receptors connected with vagal fibers exert a tonic restraining influence on renin release, and that suppression of this reflex inhibition by tilting or vagotomy leads to a sympathetically mediated increase in renin release. However, this effect can be promptly compensated by other influences, and can be overcome by intrarenal or humoral mechanisms of renin control.

Original languageEnglish
JournalCirculation Research
Volume43
Issue number1 II SUPP.1
Publication statusPublished - 1978
Externally publishedYes

    Fingerprint

Cite this

Stella, A., Dampney, R. A. L., Golin, R., & Zanchetti, A. (1978). Afferent vagal control of renin release in the anesthetized cat. Circulation Research, 43(1 II SUPP.1).