AFM study of the extracellular connective tissue matrix in patients with pelvic organ prolapse

S. L. Kotova, A. B. Shekhter, P. S. Timashev, A. E. Guller, A. A. Mudrov, V. A. Timofeeva, V. Ya Panchenko, V. N. Bagratashvili, A. B. Solovieva

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The method of atomic force microscopy (AFM) is used for the first time for morphological investigation of pathological changes in the extracellular matrix of skin connective tissue upon the prolapse of pelvic organs (common disorder among women). Skin samples of patients with clinically proven pelvic-organ prolapse and of patients that do not have any connective tissue related disease (control group) are investigated via AFM. The AFM study reveals that the extracellular matrix of the skin connective tissues from patients with pelvic-organ prolapse diverges from the normal in various organization levels including both micro- and nanotexture (packing of collagen fibers and fibrils, respectively). The results of AFM study of the normal and pathologically changed skin connective tissues are in good agreement with the data of clinical morphological analysis, which indicates the potential of AFM as an independent diagnostic tool.

Original languageEnglish
Pages (from-to)754-760
Number of pages7
JournalJournal of Surface Investigation
Volume8
Issue number4
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

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