Age-related macular degeneration and 5-year incidence of impaired activities of daily living

Bamini Gopinath, Gerald Liew, George Burlutsky, Paul Mitchell

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Objectives We aimed to assess the prospective association between age-related macular degeneration (AMD) and impaired activities of daily living (ADL) among a large cohort of older adults. Study design Functional status was determined by the Older Americans Resources and Services ADL scale from 2002-2004 to 2007-2009 among 761 participants aged 60+ years. AMD was assessed from retinal photographs. Results After adjusting for age, sex, living status, self-rated poor health, smoking, body mass index, visual impairment, hypertension, diabetes, hospital admissions in the past year, walking disability, probable depression, mini-mental state examination scores, having any AMD or late AMD increased the risk of incident impaired total ADL 5 years later, odds ratio, OR 2.87 (95% confidence intervals, CI 1.44-5.71) and OR 12.95 (95% CI 3.78-44.35), respectively. Having any AMD increased the risk of developing instrumental ADL disability over the 5 years, multivariable-adjusted OR 2.06 (95% CI 1.11-3.83). Conclusions This study shows that the presence of AMD could independently signal an increased risk of functional disability, particularly in performing instrumental ADL tasks.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
Issue number3
Publication statusPublished - Mar 2014
Externally publishedYes


  • age-related macular degeneration
  • activities of daily living
  • Blue Mountains Eye Study
  • older adults


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