Agent scheduling in unrelated parallel machines with sequence- and agent–machine–dependent setup time problem

Assignation-sequencing models have played a critical role in the competitiveness of manufacturing companies since the mid-1950s. The historic and constant evolution of these models, from simple assignations to complex constrained formulations, shows the need for, and increased interest in, more robust models. Thus, this paper presents a model to schedule agents in unrelated parallel machines that includes sequence and agent–machine-dependent setup times (ASUPM), considers an agent-to-machine relationship, and seeks to minimize the maximum makespan criteria. By depicting a more realistic scenario and to address this NP-hard problem, six mixed-integer linear formulations are proposed, and due to its ease of diversification and construct solutions, two multi-start heuristics, composed of seven algorithms, are divided into two categories: Construction of initial solution (designed algorithm) and improvement by intra (tabu search) and inter perturbation (insertions and interchanges). Three different solvers are used and compared, and heuristics algorithms are tested using randomly generated instances. It was found that models that linearizing the objective function by both job completion time and machine time is faster and related to the heuristics, and presents an outstanding level of performance in a small number of instances, since it can find the optimal value for almost every instance, has very good behavior in a medium level of instances, and decent performance in a large number of instances, where the relative deviations tend to increase concerning the small and medium instances. Additionally, two real-world applications of the problem are presented: scheduling in the automotive industry and healthcare.