Abstract
Brain-derived neurotrophic factor is a neurotrophin known to have prominent roles in maintenance, growth, and survival of neurons in the central nervous system. Brain-derived neurotrophic factor is involved in modulating synaptic plasticity and connectivity in the brain, and dysregulation of the molecule has been implicated in enhanced vulnerability to neurodegeneration and oxidative stress. The carriage of Val66Met polymorphism has effects on brain-derived neurotrophic factor secretion and has been associated with the pathophysiology of a variety of neurodegenerative and neuropsychiatric disease. The understanding of how this naturally occurring single nucleotide polymorphism impacts cognition, visual system, and brain structures in relation to aging is an essential first step in associating genetic variations in the neurotrophin system to definable biological outcomes. The purpose of this chapter was to review the recent literature that investigated the interaction between the brain-derived neurotrophic factor Val66Met and aging and established Val66Met’s important role in morphological and functional changes in humans.
| Original language | English |
|---|---|
| Title of host publication | Factors affecting neurological aging |
| Subtitle of host publication | genetics, neurology, behavior, and diet |
| Editors | Colin R. Martin, Victor R. Preedy, Rajkumar Rajendram |
| Place of Publication | United Kingdom |
| Publisher | Elsevier Academic Press |
| Chapter | 2 |
| Pages | 17-25 |
| Number of pages | 9 |
| ISBN (Electronic) | 9780128179901 |
| DOIs | |
| Publication status | Published - 1 Jan 2021 |
Keywords
- Aging
- BDNF
- Brain structure
- Neuropsychological function
- Neurotrophin
- Val66Met
- Visual system