Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Nicola J. Armstrong, Karen A. Mather, Anbupalam Thalamuthu, Margaret J. Wright, Julian N. Trollor, David Ames, Henry Brodaty, Peter R. Schofield, Perminder S. Sachdev, John B. Kwok*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

Original languageEnglish
Pages (from-to)689-700
Number of pages12
Issue number5
Publication statusPublished - 1 May 2017
Externally publishedYes


  • acceleration
  • age
  • aging
  • centenarians
  • DNAmage
  • epigenetic clock
  • longevity


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