Alcohol is an effective cue in the conditional control of tolerance to alcohol

Janet Greeley, Dzung A. Lê, Constantine X. Poulos, Howard Cappell*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    118 Citations (Scopus)


    To assess the effectiveness of a pharmacological cue as a conditional stimulus in the Pavlovian model of drug tolerance, two groups of Wistar rats received equal numbers of IP injections of a low and a high dose of alcohol. One group (Paired) received a low dose (0.8 g/kg) of alcohol followed 60 min later by the high dose (2.5 g/kg). Another group (Unpaired) received the low and high doses on an unpaired basis. When tested for tolerance to the hypothermic effect of the high dose of alcohol, only the Paired group showed tolerance, and only if the low dose preceded the high. When a saline injection preceded the high dose injection, the Paired group showed a loss of tolerance. The Paired group also showed a compensatory hyperthermia following the low dose injection. Animals from the Paired group that received repeated administrations of the low dose followed by saline, showed a significant extinction effect as compared with animals that received repeated saline injections only. These findings support the Pavlovian model of conditional tolerance, extending the realm of effective conditional stimuli to include a low dose of a drug.

    Original languageEnglish
    Pages (from-to)159-162
    Number of pages4
    Issue number2
    Publication statusPublished - May 1984


    • Alcohol
    • Conditional stimuls
    • Conditioning
    • Temperature
    • Tolerance


    Dive into the research topics of 'Alcohol is an effective cue in the conditional control of tolerance to alcohol'. Together they form a unique fingerprint.

    Cite this