Alerted microglia and the sympathetic nervous system

A novel form of microglia in the development of hypertension

Komal Kapoor, Amol M. Bhandare, Melissa M J Farnham, Paul M. Pilowsky*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Microglia, commonly known as the tissue resident macrophages of the central nervous system (CNS), are ubiquitously expressed in the CNS. Microglia, in their resting, or surveilling, stage, play a critical role in the maintenance of normal neuronal physiology and homeostasis. On activation, microglia can acquire either a neurotoxic (M1) or a neuroprotective (M2) phenotype. Prior to development of the M1 or M2 phenotype, little was known about changes in microglial activity, when subjected to stimuli. It is postulated, that an inability of microglia to maintain neuronal physiology within a normal working range can contribute to the development of cardiovascular disorders (CVDs) such as hypertension, but clear evidence supporting this hypothesis is missing. Even though our understanding of microglial function in a state of CNS injury/inflammation is extensive, the literature concerning role of microglia in the healthy CNS, is limited. Involvement of microglia in the pathophysiology of CVDs, in a neuroprotective/neurotoxic manner, is a key area that requires further investigation.

Original languageEnglish
Pages (from-to)51-62
Number of pages12
JournalRespiratory Physiology and Neurobiology
Volume226
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • Blood pressure
  • CVLM
  • Microglia
  • RVLM
  • Sympathetic nervous system

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    PACAP, sleep apnoea and high blood pressure

    Farnham, M., Pilowsky, P., Wilson, R., MQRES, M. & MQRES 3 (International), M. 3.

    1/01/1431/12/16

    Project: Research

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