Bimetallic catalysts are capable of activating alkynes to undergo a diverse array of reactions. The unique electronic structure of alkynes enables them to coordinate to two metals in a variety of different arrangements. A number of well-characterised bimetallic complexes have been discovered that utilise the versatile coordination modes of alkynes to enhance the rate of a bimetallic catalysed process. Yet, for many other bimetallic catalyst systems, which have achieved incredible improvements to a reactions rate and selectivity, the mechanism of alkyne activation remains unknown. This chapter summarises the many different approaches that bimetallic catalysts may be utilised to achieve cooperative activation of the alkyne triple bond.