Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease

Aneeza W. Hamizan*, Patricia A. Loftus, Raquel Alvarado, Jacqueline Ho, Larry Kalish, Raymond Sacks, John M. Delgaudio, Richard J. Harvey

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives/Hypothesis: Polypoid edema of the middle turbinate is a marker of inhalant allergy. Extensive edematous changes may result in limited central nasal and sinus disease, which has been called central compartment atopic disease (CCAD). Radiologically, this is seen as soft tissue thickening in the central portion of the sinonasal cavity with or without paranasal sinus involvement. When the sinuses are involved, the soft tissue thickening spares the sinus roof or lateral wall (centrally limited). This centrally limited radiological pattern was assessed among chronic rhinosinusitis (CRS) patients and compared to allergy status. Study Design: Diagnostic cross-sectional study. Methods: This study included consecutive CRS patients without prior sinus surgery. Computed tomography (CT) scans of the paranasal sinuses were blindly assessed and allergy status was confirmed by serum or skin testing. Individual sinus cavities were defined as either centrally limited or diffuse disease. The radiological pattern that may predict allergy was determined, and its diagnostic accuracy was calculated. Results: One hundred twelve patients diagnosed to have CRS, representing 224 sides, were assessed (age 46.31±13.57 years, 38.39% female, 41.07% asthma, Lund-Mackay CT score 15.88±4.35, 56.25% atopic). The radiological pattern defined by centrally limited changes in all of the paranasal sinuses was associated with allergy status (73.53% vs. 53.16%, P=.03). This predicted atopy with 90.82% specificity, 73.53% positive predictive value, likelihood positive ratios of 2.16, and diagnostic odds ratio of 4.59. Conclusions: A central radiological pattern of mucosal disease is associated with inhalant allergen sensitization. This group may represent a CCAD subgroup of patients with mainly allergic etiology.

Original languageEnglish
Pages (from-to)2015-2021
Number of pages7
JournalLaryngoscope
Volume128
Issue number9
Early online date30 Mar 2018
DOIs
Publication statusPublished - Sep 2018

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Keywords

  • Aeroallergens
  • Allergic rhinitis
  • Chronic rhinosinusitis
  • Computed tomography
  • Paranasal sinuses

Cite this

Hamizan, A. W., Loftus, P. A., Alvarado, R., Ho, J., Kalish, L., Sacks, R., ... Harvey, R. J. (2018). Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease. Laryngoscope, 128(9), 2015-2021. https://doi.org/10.1002/lary.27180