Allograft rejection and alloimmune memory in the solitary urochordate, Styela plicata

D. A. Raftos*, N. N. Tait, D. A. Briscoe

*Corresponding author for this work

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The responses of the solitary urochordate, Styela plicata, to first- and second-set tunic grafts confirm the existence of a sensitive histocompatibility system. Most first-set allografts were eliminated (median rejection time, RT50, of 38.2 ± 5.9 days) whereas the majority of autografts remained viable. Allograft rejection exhibited significant memory with second-set allografts being lost far more rapidly (RT50 = 22.0 ± 2.6 days) than first-set allografts. This alloimmune memory was shown to survive for up to 50 days after first-set rejection. Furthermore, 3rd party grafting indicated that memory was specific to the presensitizing tissue type. These results are discussed in terms of the evolution of vertebrate immunity.

Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalDevelopmental and Comparative Immunology
Volume11
Issue number2
DOIs
Publication statusPublished - 1987

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