TY - JOUR
T1 - Allograft rejection and alloimmune memory in the solitary urochordate, Styela plicata
AU - Raftos, D. A.
AU - Tait, N. N.
AU - Briscoe, D. A.
PY - 1987
Y1 - 1987
N2 - The responses of the solitary urochordate, Styela plicata, to first- and second-set tunic grafts confirm the existence of a sensitive histocompatibility system. Most first-set allografts were eliminated (median rejection time, RT50, of 38.2 ± 5.9 days) whereas the majority of autografts remained viable. Allograft rejection exhibited significant memory with second-set allografts being lost far more rapidly (RT50 = 22.0 ± 2.6 days) than first-set allografts. This alloimmune memory was shown to survive for up to 50 days after first-set rejection. Furthermore, 3rd party grafting indicated that memory was specific to the presensitizing tissue type. These results are discussed in terms of the evolution of vertebrate immunity.
AB - The responses of the solitary urochordate, Styela plicata, to first- and second-set tunic grafts confirm the existence of a sensitive histocompatibility system. Most first-set allografts were eliminated (median rejection time, RT50, of 38.2 ± 5.9 days) whereas the majority of autografts remained viable. Allograft rejection exhibited significant memory with second-set allografts being lost far more rapidly (RT50 = 22.0 ± 2.6 days) than first-set allografts. This alloimmune memory was shown to survive for up to 50 days after first-set rejection. Furthermore, 3rd party grafting indicated that memory was specific to the presensitizing tissue type. These results are discussed in terms of the evolution of vertebrate immunity.
UR - http://www.scopus.com/inward/record.url?scp=0023300691&partnerID=8YFLogxK
U2 - 10.1016/0145-305X(87)90078-4
DO - 10.1016/0145-305X(87)90078-4
M3 - Article
C2 - 3622886
AN - SCOPUS:0023300691
SN - 0145-305X
VL - 11
SP - 343
EP - 351
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 2
ER -