Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels

Hannah A. DeBerg, Shahidul M. Islam, Michael C. Puljung, Benoit Roux, William N. Zagotta, Stefan Stoll

Research output: Contribution to journalMeeting abstract


Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.
Original languageEnglish
Pages (from-to)192A-193A
Number of pages2
JournalBiophysical Journal
Issue number2
Publication statusPublished - 27 Jan 2015
Externally publishedYes


Dive into the research topics of 'Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels'. Together they form a unique fingerprint.

Cite this