Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels

Hannah A. DeBerg; Shahidul M. Islam; Michael C. Puljung; Benoit Roux; William N. Zagotta; Stefan Stoll

doi:10.1016/j.bpj.2014.11.1064

Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels

Hannah A. DeBerg, Shahidul M. Islam, Michael C. Puljung, Benoit Roux, William N. Zagotta, Stefan Stoll

Research output: Contribution to journal › Meeting abstract

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.

Original language	English
Pages (from-to)	192A-193A
Number of pages	2
Journal	Biophysical Journal
Volume	108
Issue number	2
DOIs	https://doi.org/10.1016/j.bpj.2014.11.1064
Publication status	Published - 27 Jan 2015
Externally published	Yes

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title = "Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels",

abstract = "Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.",

author = "DeBerg, {Hannah A.} and Islam, {Shahidul M.} and Puljung, {Michael C.} and Benoit Roux and Zagotta, {William N.} and Stefan Stoll",

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AU - DeBerg, Hannah A.

AU - Islam, Shahidul M.

AU - Puljung, Michael C.

AU - Roux, Benoit

AU - Zagotta, William N.

AU - Stoll, Stefan

PY - 2015/1/27

Y1 - 2015/1/27

N2 - Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.

AB - Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.

U2 - 10.1016/j.bpj.2014.11.1064

DO - 10.1016/j.bpj.2014.11.1064

M3 - Meeting abstract

VL - 108

SP - 192A-193A

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 2

ER -

Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels

Abstract

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