Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels

Hannah A. DeBerg, Shahidul M. Islam, Michael C. Puljung, Benoit Roux, William N. Zagotta, Stefan Stoll

Research output: Contribution to journalMeeting abstract

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating pacemaking activity in the heart and brain. They are regulated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides increases the rate and extent of activation of the channels and shifts channel activation to less hyperpolarized voltages. In intact channels, cAMP and cGMP are full agonists and cCMP is a partial agonist.
Original languageEnglish
Pages (from-to)192A-193A
Number of pages2
JournalBiophysical Journal
Volume108
Issue number2
DOIs
Publication statusPublished - 27 Jan 2015
Externally publishedYes

Cite this

DeBerg, H. A., Islam, S. M., Puljung, M. C., Roux, B., Zagotta, W. N., & Stoll, S. (2015). Allosteric regulation of the cyclic nucleotide-binding domain in HCN channels. Biophysical Journal, 108(2), 192A-193A. https://doi.org/10.1016/j.bpj.2014.11.1064