Alterations in central hemodynamic in patients with COPD after acute high intensity exercise

M. Behnia; C. M. Wheatley-Guy; B. D. Johnson; A. Avolio; C.-H. Kim

doi:10.1016/j.pulmoe.2020.06.006

Alterations in central hemodynamic in patients with COPD after acute high intensity exercise

M. Behnia, C. M. Wheatley-Guy, B. D. Johnson, A. Avolio, C.-H. Kim^*

^*Corresponding author for this work

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Abstract

The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.

Original language	English
Pages (from-to)	215-218
Number of pages	4
Journal	Pulmonology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.pulmoe.2020.06.006
Publication status	Published - 1 May 2021

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Copyright Sociedade Portuguesa de Pneumologia 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Central aortic pressure
COPD
Lung function

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Publisher version (open access)Final published version, 288 KBLicence: CC BY-NC-ND

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title = "Alterations in central hemodynamic in patients with COPD after acute high intensity exercise",

abstract = "The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.",

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AU - Wheatley-Guy, C. M.

AU - Johnson, B. D.

AU - Avolio, A.

AU - Kim, C.-H.

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N2 - The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.

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Alterations in central hemodynamic in patients with COPD after acute high intensity exercise

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