Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Rebecca Kerestes; Pramit M. Phal; Chris Steward; Bradford A. Moffat; Simon Salinas; Kay L Cox; Kathryn A. Ellis; Elizabeth V Cyarto; David Ames; Ralph Martins; Colin L. Masters; Christopher C. Rowe; Matthew J. Sharman; Olivier Salvado; Cassandra Szoeke; Michelle Lai; Nicola T. Lautenschlager; Patricia M. Desmond

doi:10.1192/bjpo.bp.115.001339

Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Rebecca Kerestes, Pramit M. Phal, Chris Steward, Bradford A. Moffat, Simon Salinas, Kay L Cox, Kathryn A. Ellis, Elizabeth V Cyarto, David Ames, Ralph Martins, Colin L. Masters, Christopher C. Rowe, Matthew J. Sharman, Olivier Salvado, Cassandra Szoeke, Michelle Lai, Nicola T. Lautenschlager, Patricia M. Desmond

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Abstract

Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele. Method Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4-; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC-SMA connectivity. Conclusions The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

Original language	English
Pages (from-to)	139-148
Number of pages	18
Journal	BJPsych Open
Volume	1
Issue number	2
DOIs	https://doi.org/10.1192/bjpo.bp.115.001339
Publication status	Published - Oct 2015
Externally published	Yes

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Copyright the Publisher 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1192/bjpo.bp.115.001339

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Kerestes, R., Phal, P. M., Steward, C., Moffat, B. A., Salinas, S., Cox, K. L., Ellis, K. A., Cyarto, E. V., Ames, D., Martins, R., Masters, C. L., Rowe, C. C., Sharman, M. J., Salvado, O., Szoeke, C., Lai, M., Lautenschlager, N. T., & Desmond, P. M. (2015). Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease. BJPsych Open, 1(2), 139-148. https://doi.org/10.1192/bjpo.bp.115.001339

@article{e88e5536400645718cbe6585cfc3b9a9,

title = "Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease",

abstract = "Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele. Method Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4-; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC-SMA connectivity. Conclusions The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.",

author = "Rebecca Kerestes and Phal, {Pramit M.} and Chris Steward and Moffat, {Bradford A.} and Simon Salinas and Cox, {Kay L} and Ellis, {Kathryn A.} and Cyarto, {Elizabeth V} and David Ames and Ralph Martins and Masters, {Colin L.} and Rowe, {Christopher C.} and Sharman, {Matthew J.} and Olivier Salvado and Cassandra Szoeke and Michelle Lai and Lautenschlager, {Nicola T.} and Desmond, {Patricia M.}",

note = "Copyright the Publisher 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2015",

month = oct,

doi = "10.1192/bjpo.bp.115.001339",

language = "English",

volume = "1",

pages = "139--148",

journal = "BJPsych Open",

issn = "2056-4724",

publisher = "Cambridge University Press (CUP)",

number = "2",

}

Kerestes, R, Phal, PM, Steward, C, Moffat, BA, Salinas, S, Cox, KL, Ellis, KA, Cyarto, EV, Ames, D, Martins, R, Masters, CL, Rowe, CC, Sharman, MJ, Salvado, O, Szoeke, C, Lai, M, Lautenschlager, NT & Desmond, PM 2015, 'Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease', BJPsych Open, vol. 1, no. 2, pp. 139-148. https://doi.org/10.1192/bjpo.bp.115.001339

TY - JOUR

T1 - Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

AU - Kerestes, Rebecca

AU - Phal, Pramit M.

AU - Steward, Chris

AU - Moffat, Bradford A.

AU - Salinas, Simon

AU - Cox, Kay L

AU - Ellis, Kathryn A.

AU - Cyarto, Elizabeth V

AU - Ames, David

AU - Martins, Ralph

AU - Masters, Colin L.

AU - Rowe, Christopher C.

AU - Sharman, Matthew J.

AU - Salvado, Olivier

AU - Szoeke, Cassandra

AU - Lai, Michelle

AU - Lautenschlager, Nicola T.

AU - Desmond, Patricia M.

N1 - Copyright the Publisher 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/10

Y1 - 2015/10

N2 - Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele. Method Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4-; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC-SMA connectivity. Conclusions The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

AB - Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele. Method Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4-; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC-SMA connectivity. Conclusions The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

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U2 - 10.1192/bjpo.bp.115.001339

DO - 10.1192/bjpo.bp.115.001339

M3 - Article

C2 - 27703739

SN - 2056-4724

VL - 1

SP - 139

EP - 148

JO - BJPsych Open

JF - BJPsych Open

IS - 2

ER -

Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

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