Alterations in plasma electrolytes and serum liver enzymes induced by atenolol in common rabbits Oryctolagus cuniculus

Ruqaiya Hasan*, Aisha Javaid, Habib Fatima, Wajeeha Safdar

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    Abstract

    This study is done to find out the effects of atenolol on plasma electrolytes sodium, potassium, calcium and on serum enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of common rabbits Oryctolagus cuniculus following the administration of an oral daily dose of 0.6 mg atenolol for 27 days. Observations showed a non-significant rise in sodium concentration, a significant elevation and ultimate fall of potassium concentration and reduction of calcium levels significantly to half of the normal values. These findings suggest the diuretic action of drug; possibly the prolonged use cause the renal dysfunction. Long-term treatment of hypertension by atenolol may impair the hepatic function indicated by significant very low and high levels of serum AST and ALT, respectively.

    Original languageEnglish
    Pages (from-to)2342-2345
    Number of pages4
    JournalPakistan Journal of Biological Sciences
    Volume9
    Issue number12
    DOIs
    Publication statusPublished - Dec 2006

    Keywords

    • β-blocker
    • Antihypertensive
    • Atenolol
    • Electrolytes

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