TY - JOUR
T1 - Alterations of blood IL-8, TGF-β1 and nitric oxide levels in relation to blood cells in patients with acute brain injury
AU - Hadidi, Elham
AU - Mojtahedzadeh, Mojtaba
AU - Paknejad, Mohammad Hassan
AU - Nikfar, Shekoufeh
AU - Zamani, Mohammad Jafar
AU - Sahraian, Mohammad Ali
AU - Eftekhar, Behzad
AU - Khajavi, Mohammad R.
AU - Najafi, Atabak
AU - Ghaffarzadeh, Mahtab
AU - Eftekhari, Righieh
AU - Soleimani, Venus
AU - Esmaily, Hadi
AU - Rouini, Mohammad Reza
AU - Abdollahi, Mohammad
PY - 2006
Y1 - 2006
N2 - Background: Acute brain injury (ABI) disrupts homeostasis in tissue brain. Inflammation has an important contributory role in the pathogenesis of the disease and blood cell count alteration has been shown. The clinical course is variable, and the factors or markers available for predicting survival or the functional situation of these patients are limited. Aim: The aim of this study was to measure the serum levels of interleukin (IL)-8, transforming growth factor (TGF)-β1 and nitric oxide (NO) in patients with ABI (at days 1, 2, 3 and 7) and to study their relationships to blood cell counts. Methods & results: A total of 25 patients were included in the study and 15 healthy subjects were chosen as a control group. Expression of IL-8 and TGF-β1 and production of NO were higher in ABI patients at each of the time points as compared with the control group. In the case of TGF-β1, the increase at time points 3 and 7 was greater than time points 1 and 2. White blood cells were increased significantly (12130 ± 1372 cells/μl; p < 0.01). A huge decrease in platelet counts was also observed (202 ± 14 cells/μl; p < 0.01). Interestingly, no significant correlation was found between the serum levels of these mediators and blood cell counts (mainly considered leukocytes and platelets). Discussion & conclusion: This study shows dramatic increase in the serum levels of three important mediators involved in inflammation and progression of ABI. We showed that there is no correlation between the serum levels of these mediators, leukocytes and platelets and probably they act independently from each other.
AB - Background: Acute brain injury (ABI) disrupts homeostasis in tissue brain. Inflammation has an important contributory role in the pathogenesis of the disease and blood cell count alteration has been shown. The clinical course is variable, and the factors or markers available for predicting survival or the functional situation of these patients are limited. Aim: The aim of this study was to measure the serum levels of interleukin (IL)-8, transforming growth factor (TGF)-β1 and nitric oxide (NO) in patients with ABI (at days 1, 2, 3 and 7) and to study their relationships to blood cell counts. Methods & results: A total of 25 patients were included in the study and 15 healthy subjects were chosen as a control group. Expression of IL-8 and TGF-β1 and production of NO were higher in ABI patients at each of the time points as compared with the control group. In the case of TGF-β1, the increase at time points 3 and 7 was greater than time points 1 and 2. White blood cells were increased significantly (12130 ± 1372 cells/μl; p < 0.01). A huge decrease in platelet counts was also observed (202 ± 14 cells/μl; p < 0.01). Interestingly, no significant correlation was found between the serum levels of these mediators and blood cell counts (mainly considered leukocytes and platelets). Discussion & conclusion: This study shows dramatic increase in the serum levels of three important mediators involved in inflammation and progression of ABI. We showed that there is no correlation between the serum levels of these mediators, leukocytes and platelets and probably they act independently from each other.
KW - Acute brain injury
KW - Biomarker
KW - Cytokine
KW - Interleukine
KW - Nitric oxide
KW - Transforming growth factor
UR - http://www.scopus.com/inward/record.url?scp=33745077358&partnerID=8YFLogxK
U2 - 10.2217/14750708.3.3.399
DO - 10.2217/14750708.3.3.399
M3 - Article
AN - SCOPUS:33745077358
SN - 1475-0708
VL - 3
SP - 399
EP - 405
JO - Therapy
JF - Therapy
IS - 3
ER -