Altered brain myelin sheath morphology after rewarming in situ

E. S. Dietrichs, S. Lindal, T. Naesheim, T. Ingebrigtsen, T. Tveita*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (1513°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100β (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalUltrastructural Pathology
Volume34
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Hypothermia
  • Myelin damage
  • Rewarming
  • Ultra structure

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