Altered brain myelin sheath morphology after rewarming in situ

E. S. Dietrichs; S. Lindal; T. Naesheim; T. Ingebrigtsen; T. Tveita

doi:10.3109/01913120903398753

Altered brain myelin sheath morphology after rewarming in situ

E. S. Dietrichs, S. Lindal, T. Naesheim, T. Ingebrigtsen, T. Tveita^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (1513°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100β (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.

Original language	English
Pages (from-to)	82-89
Number of pages	8
Journal	Ultrastructural Pathology
Volume	34
Issue number	2
DOIs	https://doi.org/10.3109/01913120903398753
Publication status	Published - 2010
Externally published	Yes

Keywords

Hypothermia
Myelin damage
Rewarming
Ultra structure

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10.3109/01913120903398753

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title = "Altered brain myelin sheath morphology after rewarming in situ",

abstract = "In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (1513°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100β (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.",

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T1 - Altered brain myelin sheath morphology after rewarming in situ

AU - Dietrichs, E. S.

AU - Lindal, S.

AU - Naesheim, T.

AU - Ingebrigtsen, T.

AU - Tveita, T.

PY - 2010

Y1 - 2010

N2 - In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (1513°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100β (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.

AB - In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (1513°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100β (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.

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