Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Anneliese B. New; Donald A. Robin; Amy L. Parkinson; Joseph R. Duffy; Malcom R. McNeil; Olivier Piguet; Michael Hornberger; Cathy J. Price; Simon B. Eickhoff; Kirrie J. Ballard

doi:10.1016/j.nicl.2015.03.013

Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Anneliese B. New, Donald A. Robin^*, Amy L. Parkinson, Joseph R. Duffy, Malcom R. McNeil, Olivier Piguet, Michael Hornberger, Cathy J. Price, Simon B. Eickhoff, Kirrie J. Ballard

^*Corresponding author for this work

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Abstract

Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

Original language	English
Pages (from-to)	429-439
Number of pages	11
Journal	NeuroImage: Clinical
Volume	8
DOIs	https://doi.org/10.1016/j.nicl.2015.03.013
Publication status	Published - 8 Jun 2015
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Apraxia of speech
Network connectivity
Resting-state fMRI
Stroke

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Publisher version (open access)Final published version, 1.27 MBLicence: CC BY-NC-ND

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title = "Altered resting-state network connectivity in stroke patients with and without apraxia of speech",

abstract = "Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.",

keywords = "Apraxia of speech, Network connectivity, Resting-state fMRI, Stroke",

author = "New, {Anneliese B.} and Robin, {Donald A.} and Parkinson, {Amy L.} and Duffy, {Joseph R.} and McNeil, {Malcom R.} and Olivier Piguet and Michael Hornberger and Price, {Cathy J.} and Eickhoff, {Simon B.} and Ballard, {Kirrie J.}",

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doi = "10.1016/j.nicl.2015.03.013",

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AU - New, Anneliese B.

AU - Robin, Donald A.

AU - Parkinson, Amy L.

AU - Duffy, Joseph R.

AU - McNeil, Malcom R.

AU - Piguet, Olivier

AU - Hornberger, Michael

AU - Price, Cathy J.

AU - Eickhoff, Simon B.

AU - Ballard, Kirrie J.

N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/6/8

Y1 - 2015/6/8

N2 - Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

AB - Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

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KW - Network connectivity

KW - Resting-state fMRI

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ER -

Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Abstract

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Keywords

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