Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Anneliese B. New, Donald A. Robin*, Amy L. Parkinson, Joseph R. Duffy, Malcom R. McNeil, Olivier Piguet, Michael Hornberger, Cathy J. Price, Simon B. Eickhoff, Kirrie J. Ballard

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

Original languageEnglish
Pages (from-to)429-439
Number of pages11
JournalNeuroImage: Clinical
Volume8
DOIs
Publication statusPublished - 8 Jun 2015
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Apraxia of speech
  • Network connectivity
  • Resting-state fMRI
  • Stroke

Fingerprint Dive into the research topics of 'Altered resting-state network connectivity in stroke patients with and without apraxia of speech'. Together they form a unique fingerprint.

  • Cite this

    New, A. B., Robin, D. A., Parkinson, A. L., Duffy, J. R., McNeil, M. R., Piguet, O., ... Ballard, K. J. (2015). Altered resting-state network connectivity in stroke patients with and without apraxia of speech. NeuroImage: Clinical, 8, 429-439. https://doi.org/10.1016/j.nicl.2015.03.013