Alzheimer's disease and frontotemporal dementia

prospects of a tailored therapy?

Jürgen Götz*, Lars M. Ittner, Nicole Schonrock

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

• Alzheimer's disease (AD) is the most prevalent dementia (accounting for 50%-75% of cases of dementia in people aged over 65 years), followed by frontotemporal dementia (FTD) (10%-20% of cases). 

• AD is characterised histopathologically by Aβ-containing amyloid plaques and tau-containing neurofibrillary tangles, whereas FTD exhibits neurofibrillary tangles alone.

• Current symptomatic treatments of AD are of limited benefit, as they are not directed at the underlying biological basis of the disease. 

• The development of transgenic animal models has provided insight into disease mechanisms and helped define novel drug targets. 

• More than 50 drugs are currently in clinical trials, and novel and more effective drugs targeting both AD and FTD are expected to become available within 5-10 years.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalMedical Journal of Australia
Volume185
Issue number7
Publication statusPublished - 2 Oct 2006
Externally publishedYes

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