Alzheimer’s disease and frontotemporal lobar degeneration

mouse models

Lars M. Ittner*, Wei S. Lee, Kristie Stefanoska, Prita R. Asih, Yazi D. Ke

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Genetically modified mouse models have been instrumental in deciphering pathomechanisms in a large variety of human conditions. Accordingly, transgenic and knockout mice have contributed to understanding neurodegenerative processes in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). While initial models for AD and FTLD based on mutations in APP and tau have been generated more than a decade ago, identification of novel genes involved in disease has markedly increased the spectrum of available FTLD mouse models. This chapter provides an overview of APP and tau-based mouse models of AD and FTLD and how these models have advanced our understanding of disease mechanisms as well as discusses more recent FTLD models of novel disease genes.

Original languageEnglish
Title of host publicationNeurodegeneratIve diseases
Subtitle of host publicationclinical aspects, molecular genetics and biomarkers
EditorsDaniela Galimberti, Elio Scarpini
PublisherSpringer, Springer Nature
Pages187-219
Number of pages33
EditionSecond
ISBN (Electronic)9783319729381
ISBN (Print)9783319729374
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Keywords

  • APP
  • FUS
  • Mouse model
  • Tau
  • TDP-43

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  • Cite this

    Ittner, L. M., Lee, W. S., Stefanoska, K., Asih, P. R., & Ke, Y. D. (2018). Alzheimer’s disease and frontotemporal lobar degeneration: mouse models. In D. Galimberti, & E. Scarpini (Eds.), NeurodegeneratIve diseases: clinical aspects, molecular genetics and biomarkers (Second ed., pp. 187-219). Springer, Springer Nature. https://doi.org/10.1007/978-3-319-72938-1_10