Alzheimer's disease and frontotemporal lobar degeneration

mouse models

Janet van Eersel, Fabien Delerue, Lars M. Ittner*, Yazi D. Ke

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Genetically modified mouse models have been instrumental in deciphering pathomechanisms in a large variety of human conditions. Similarly, transgenic and knockout mice have contributed to understanding neurodegenerative processes in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). While the first models for AD and FTLD, based on mutations in APP and tau, respectively, have been generated more than a decade ago, recent years have seen the identification of new genes involved in the disease. This led to the generation of a large number of new transgenic mouse models for FTLD. This chapter provides an overview of APP and tau-based mouse models of AD and FTLD and discusses in detail the more recent FTLD models expressing novel disease genes.

Original languageEnglish
Title of host publicationNeurodegenerative diseases
Subtitle of host publicationclinical aspects, molecular genetics and biomarkers
EditorsDaniela Galimberti, Elio Scarpini
PublisherSpringer, Springer Nature
Chapter8
Pages111-129
Number of pages19
ISBN (Electronic)9781447163800
ISBN (Print)1447163796, 9781447163794
DOIs
Publication statusPublished - 1 Mar 2014
Externally publishedYes

Keywords

  • APP
  • FUS
  • Mouse model
  • Tau
  • TDP-43

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