Alzheimer's disease and frontotemporal lobar degeneration: mouse models

Janet van Eersel; Fabien Delerue; Lars M. Ittner; Yazi D. Ke

doi:10.1007/978-1-4471-6380-0_8

Alzheimer's disease and frontotemporal lobar degeneration: mouse models

Janet van Eersel, Fabien Delerue, Lars M. Ittner^*, Yazi D. Ke

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Genetically modified mouse models have been instrumental in deciphering pathomechanisms in a large variety of human conditions. Similarly, transgenic and knockout mice have contributed to understanding neurodegenerative processes in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). While the first models for AD and FTLD, based on mutations in APP and tau, respectively, have been generated more than a decade ago, recent years have seen the identification of new genes involved in the disease. This led to the generation of a large number of new transgenic mouse models for FTLD. This chapter provides an overview of APP and tau-based mouse models of AD and FTLD and discusses in detail the more recent FTLD models expressing novel disease genes.

Original language	English
Title of host publication	Neurodegenerative diseases
Subtitle of host publication	clinical aspects, molecular genetics and biomarkers
Editors	Daniela Galimberti, Elio Scarpini
Publisher	Springer, Springer Nature
Chapter	8
Pages	111-129
Number of pages	19
ISBN (Electronic)	9781447163800
ISBN (Print)	1447163796, 9781447163794
DOIs	https://doi.org/10.1007/978-1-4471-6380-0_8
Publication status	Published - 1 Mar 2014
Externally published	Yes

Keywords

APP
FUS
Mouse model
Tau
TDP-43

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10.1007/978-1-4471-6380-0_8

Cite this

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Alzheimer's disease and frontotemporal lobar degeneration : mouse models. / van Eersel, Janet ; Delerue, Fabien ; Ittner, Lars M.; Ke, Yazi D.

Neurodegenerative diseases: clinical aspects, molecular genetics and biomarkers. ed. / Daniela Galimberti; Elio Scarpini. Springer, Springer Nature, 2014. p. 111-129.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Alzheimer's disease and frontotemporal lobar degeneration: mouse models

Abstract

Keywords

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