@inbook{8954826a3b9048a6810fab7b59c7fa09,
title = "Alzheimer{\textquoteright}s disease: insights from genetic mouse models and current advances in human IPSC-derived neurons",
abstract = "Alzheimer{\textquoteright}s disease was first described in 1906 and since then tremendous efforts have been made to fully understand the disease pathology and to find a cure for this neurodegenerative disease. The diagnosis of Alzheimer{\textquoteright}s is still difficult, especially in early stages of the disease. Current treatment of Alzheimer{\textquoteright}s only ameliorates the symptoms but fails to provide a therapy. Over the last decades, animal models have been proven valuable in elucidating insights of the pathology. In vitro models using patient-derived cells are currently emerging and hold great promise in understanding the disease pathophysiology. Here, we introduce the neurobiology and genetic features of Alzheimer{\textquoteright}s and describe what we have learned from studies employing mouse models and patient-derived induced pluripotent stem cells.",
keywords = "Alzheimer{\textquoteright}s disease, Amyloid-β, Excitotoxicity, Induced pluripotent stem cells, Mouse models, Tau",
author = "Harasta, {Anne E.} and Ittner, {Lars M.}",
year = "2017",
month = jan,
day = "1",
doi = "10.1007/978-3-319-57193-5_1",
language = "English",
isbn = "9783319571911",
series = "Advances in Neurobiology",
publisher = "Springer, Springer Nature",
pages = "3--29",
editor = "Philip Beart and Michael Robinson and Marcus Rattray and Maragakis, {Nicholas J.}",
booktitle = "Neurodegenerative diseases",
address = "United States",
}