Alzheimer’s disease

insights from genetic mouse models and current advances in human IPSC-derived neurons

Anne E. Harasta*, Lars M. Ittner

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Alzheimer’s disease was first described in 1906 and since then tremendous efforts have been made to fully understand the disease pathology and to find a cure for this neurodegenerative disease. The diagnosis of Alzheimer’s is still difficult, especially in early stages of the disease. Current treatment of Alzheimer’s only ameliorates the symptoms but fails to provide a therapy. Over the last decades, animal models have been proven valuable in elucidating insights of the pathology. In vitro models using patient-derived cells are currently emerging and hold great promise in understanding the disease pathophysiology. Here, we introduce the neurobiology and genetic features of Alzheimer’s and describe what we have learned from studies employing mouse models and patient-derived induced pluripotent stem cells.

Original languageEnglish
Title of host publicationNeurodegenerative diseases
Subtitle of host publicationpathology, mechanisms, and potential therapeutic targets
EditorsPhilip Beart, Michael Robinson, Marcus Rattray, Nicholas J. Maragakis
PublisherSpringer, Springer Nature
Chapter1
Pages3-29
Number of pages27
ISBN (Electronic)9783319571935
ISBN (Print)9783319571911
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Publication series

NameAdvances in Neurobiology
Volume15
ISSN (Print)2190-5215

Keywords

  • Alzheimer’s disease
  • Amyloid-β
  • Excitotoxicity
  • Induced pluripotent stem cells
  • Mouse models
  • Tau

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  • Cite this

    Harasta, A. E., & Ittner, L. M. (2017). Alzheimer’s disease: insights from genetic mouse models and current advances in human IPSC-derived neurons. In P. Beart, M. Robinson, M. Rattray, & N. J. Maragakis (Eds.), Neurodegenerative diseases: pathology, mechanisms, and potential therapeutic targets (pp. 3-29). (Advances in Neurobiology; Vol. 15). Springer, Springer Nature. https://doi.org/10.1007/978-3-319-57193-5_1