Amplification of the VB-12 uptake system using polymers

Alison Ruth Gould; Bernard Vincent McInerney; Gregory John Russell-Jones; Steven William Westwood

Amplification of the VB-12 uptake system using polymers

Alison Ruth Gould (Inventor), Bernard Vincent McInerney (Inventor), Gregory John Russell-Jones (Inventor), Steven William Westwood (Inventor)

Research output: Patent

Abstract

The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B₁₂ (VB₁₂) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V - Q)_n- P - (Q' - A)_m, where V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B₁₂ or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.

Original language	English
Patent number	AU1994067903
IPC	C07K 7/02,A61K 31/714,A61K 38/00,A61K 47/48,C07K 1/113,C07K 7/23,C07K 14/00,C07K 14/54,C07K 14/555,C07K 14/575,C07K 17/06,C07K 17/08,C07K 17/10,A61K 38/04,A61K 38/21,A61K 38/22
Priority date	24/05/93
Publication status	Published - 7 Oct 1999
Externally published	Yes

Access to Document

https://patentscope.wipo.int/search/en/detail.jsf?docId=AU180621369

Cite this

@misc{c01e5eff3a02454e883c15d63cba60d6,

title = "Amplification of the VB-12 uptake system using polymers",

abstract = "The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B12 (VB12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V - Q)n- P - (Q' - A)m, where V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.",

author = "Gould, {Alison Ruth} and McInerney, {Bernard Vincent} and Russell-Jones, {Gregory John} and Westwood, {Steven William}",

year = "1999",

month = oct,

day = "7",

language = "English",

type = "Patent",

note = "AU1994067903; C07K 7/02,A61K 31/714,A61K 38/00,A61K 47/48,C07K 1/113,C07K 7/23,C07K 14/00,C07K 14/54,C07K 14/555,C07K 14/575,C07K 17/06,C07K 17/08,C07K 17/10,A61K 38/04,A61K 38/21,A61K 38/22",

}

TY - PAT

T1 - Amplification of the VB-12 uptake system using polymers

AU - Gould, Alison Ruth

AU - McInerney, Bernard Vincent

AU - Russell-Jones, Gregory John

AU - Westwood, Steven William

PY - 1999/10/7

Y1 - 1999/10/7

N2 - The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B12 (VB12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V - Q)n- P - (Q' - A)m, where V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.

AB - The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B12 (VB12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V - Q)n- P - (Q' - A)m, where V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.

M3 - Patent

M1 - AU1994067903

ER -

Amplification of the VB-12 uptake system using polymers

Abstract

Access to Document

Fingerprint

Cite this