Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

Christopher C. Rowe*, Kathryn A. Ellis, Miroslava Rimajova, Pierrick Bourgeat, Kerryn E. Pike, Gareth Jones, Jurgen Fripp, Henri Tochon-Danguy, Laurence Morandeau, Graeme O'Keefe, Roger Price, Parnesh Raniga, Peter Robins, Oscar Acosta, Nat Lenzo, Cassandra Szoeke, Olivier Salvado, Richard Head, Ralph Martins, Colin L. MastersDavid Ames, Victor L. Villemagne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

702 Citations (Scopus)

Abstract

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed 11C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-ε4 carriers vs 21% in noncarriers) and increased with age, most strongly in ε4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in ε4 carriers. There was no correlation with cognition in HC or MCI. PiB binding in AD was unrelated to age, hippocampal volume or memory. Beta-amyloid (Aβ) deposition seems almost inevitable with advanced age, amyloid burden is similar at all ages in AD, and secondary factors or downstream events appear to play a more direct role than total beta amyloid burden in hippocampal atrophy and cognitive decline.

Original languageEnglish
Pages (from-to)1275-1283
Number of pages9
JournalNeurobiology of Aging
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid imaging
  • Magnetic resonance imaging
  • Mild cognitive impairment
  • Positron emission tomography

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