An anatomical and physiological basis for CSF pathway disorders

Andrew Brodbelt*, Marcus Stoodley

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    2 Citations (Scopus)


    More than 60% of the human body weight is made of water (1). Water surrounds, permeates, flows, and forms an integral component of the brain and the spinal cord. Cerebrospinal fluid (CSF) is one part of this integrated system. CSF has important mechanical and biochemical functions and is actively produced at a rate of 500 mL/day, circulates through the ventricles, subarachnoid space and parenchyma, and is reabsorbed into the venous circulation (Fig. 1). Failures of this system manifest as clinical CSF disorders. This chapter reviews current concepts of the relevant anatomy and physiology to provide a basis for understanding CSF pathway disorders, and existing and future treatment options.

    Original languageEnglish
    Title of host publicationCerebrospinal fluid disorders
    EditorsConor Mallucci, Spyros Sgouros
    Place of PublicationNew York
    PublisherInforma Healthcare
    Number of pages17
    ISBN (Electronic)9781420016284
    ISBN (Print)9780824728335
    Publication statusPublished - 2010


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