An Androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug

Martin Huxley, Carlos Sanchez-Cano, Michael J. Browning, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Alison Rodger, Michael J. Hannon

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(II) complexes from the inactive components.
Original languageEnglish
Pages (from-to)11353-11364
Number of pages12
JournalDalton Transactions
Volume39
Issue number47
DOIs
Publication statusPublished - 2010
Externally publishedYes

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