An assessment of the effects of internal neurolysis on a chronically compressed rat sciatic nerve

S. E. Mackinnon, J. P. O’Brien, A. L. Dellon, A. R. McLean, A. R. Hudson, D. A. Hunter, Graham J. Gumley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Chronically compressed nerves were treated with three surgical modalities. Simple decompression was compared to internal neurolysis with and without the addition of extrafascicular steroid. Electrophysiologic, histologic, and morphometric assessments were performed. Compressed control nerves demonstrated changes compatible with severe nerve compression (Wallerian degeneration). With simple decompression, improvement in histologic and electrophysiologic parameters occurred. When internal neurolysis was added to the decompression, further improvement in histologic and electrophysiologic parameters was noted. There was no added improvement with the addition of steroids.
Original languageEnglish
Pages (from-to)257-258
Number of pages2
JournalPlastic and Reconstructive Surgery
Volume81
Issue number2
Publication statusPublished - 1988

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