The electron donating properties of the drugs, amiodarone, desethylamiodarone, promethazine and codeine have been studied using the electrochemical technique of conductivity titration, complemented by electronic absorption spectroscopy. All were found to form charge transfer complexes in vitro with the electron acceptor iodine in acetonitrile. A quantitative explanation has been proposed to account for the observed temperature dependence of the conductivity. This is based on consideration of the opposing effects of charge mobility and the temperature-dependent donor-acceptor equilibrium. An assessment of the use of the hydrochloride form, instead of free base, of drugs in examining the model systems for the study of drug donor-acceptor interactions is also presented.
- charge-transfer complexes
- drug molecules