Projects per year
The design of wound dressing hydrogels is of utmost importance in healthcare with desired remedial effects, self-healing ability, cell affinity, and appropriate mechanical properties, particularly for healing skin wounds; excellent wound tissue adhesiveness is imperative. Here, an ultra-tough and self-healable double-network (DN) hydrogel is designed based on salep/poly(vinyl alcohol) that is endowed with superior tissue adhesiveness and cell affinity as demonstrated for critical and burn wound healing in rats. The self-healing capability of the hydrogel is attainedviahydrogen bonds and Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) chains (OSEA network). The interaction of hydroxyl groups of the poly(vinyl alcohol) (PVA) network effectively facilitates to create a stable mechanical structure and endow self-healing ability. The ensuing novel hydrogel is endowed with excellent self-healing ability, high mechanical strength (Young's modulus of up to 14 kPa; high fracture energy of up to 90 kJ m−3; compressive stress of 400 kPa), good tissue adhesiveness (up to 48 N m−1adhesive strength), and superior therapeutic properties (cell viability of A375 cells >80%; remarkable healing of >60% in 14 and >98% in 21 days). The macroscopic evaluation revealed healing >80% in 14 days and 100% in 21 days that is achieved by combining both networks in a single system along withArnebiaextract and Ag nanoparticles (Ag NPs) in green media.In vitroandin vivotests affirmed that the PVA/OSEA DN hydrogel could be an excellent candidate for skin tissue regeneration in medical applications.
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- 1 Active
Rabiee, N., Webster, T. J., Varma, R. S., Makvandi, P., Rabiee, M., Rahimnejad, M., Jahangiri, S., Ahmadi, S. & Tavakolizadeh, M.
10/09/18 → …