An evaluation of prosthetic femoral head impact on acetabular articular cartilage in a hemiarthroplasty model

J. R. Field, R. Stanley, R. Appleyard, M. McGee, S. Callary, K. Nilsson

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objectives: The quantitation of the impact of hemiar-throplasty currently involves clinical outcome measures and radiographic evaluation. This study used in vivo and in vitro means in order to evaluate articular cartilage changes following hemiarthroplasty in the sheep. Methods: Radiostereometric analysis (RSA) was utilized in order to quantitate migration (penetration) in vivo of the femoral head into the articular cartilage of the acetabulum. Dynamic stiffness of retrieved specimens was quantitated in vitro using a handheld device. Chondrocyte viability was assessed using live/dead cell staining and quantitated using image analysis techniques. Saffranin-O staining provided histological assessment of the cellular response to hemiarthroplasty. Results: RSA showed rapid penetration of the femoral head into the acetabular cartilage over six months. Significantly higher levels of dynamic stiffness were observed in the acetabula following hemiarthroplasty. Confocal imagery highlighted changes in chondrocyte distribution and morphology. A loss of metachromasia, fibrovascular tissue invasion and apoptosis were observed histologically. Conclusions: RSA and measurement of the dynamic mechanical characteristics of cartilage provide a means of evaluating the development of degenerative articular cartilage changes in response to hemiarthroplasty.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalVeterinary and Comparative Orthopaedics and Traumatology
Volume22
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

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