An evaluation of the techniques employed to investigate powder compaction behaviour

Ian Krycer*, David G. Pope, John A. Hersey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Employing 4 model powders, Avicel, Dipac, mannitol and paracetamol and a single-punch tablet machine, the most common techniques used to investigate powder compaction behaviour are compared and assessed. The use of tablet tensile strength rather than crushing force is found to bias the interpretation of lower punch work (LPW1)/hardness profiles when compacts of very different thicknesses are produced. Radial versus axial pressure cycles, maximum die wall pressure and lower punch work on recompression (LPW2) are demonstrated to be insensitive comparative measurements of compaction behaviour. Further, the latter suffers from considerable interpretive difficulties. Stress relaxation measurements are employed to verify data obtained from residual die wall pressure determinations and Heckel plots. Thus, the use of LPW1 /crushing force profiles, residual die wall pressure versus axial pressure and elastic recovery versus LPW1 plots are simple and efficient techniques that assist in defining powder compaction behaviour.

Original languageEnglish
Pages (from-to)113-134
Number of pages22
JournalInternational Journal of Pharmaceutics
Volume12
Issue number2-3
DOIs
Publication statusPublished - 1982
Externally publishedYes

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