TY - JOUR
T1 - An increasing incidence of upper gastrointestinal disorders over 23 Years
T2 - a prospective population-based study in Sweden
AU - Andreasson, Anna
AU - Talley, Nicholas J.
AU - Walker, Marjorie M.
AU - Jones, Michael P.
AU - Platts, Loretta G.
AU - Wallner, Bengt
AU - Kjellström, Lars
AU - Hellström, Per M.
AU - Forsberg, Anna
AU - Agréus, Lars
PY - 2021/1
Y1 - 2021/1
N2 - INTRODUCTION: We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing. METHODS: Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21-79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22-80 years, rr = 87%), 1995 (n = 1,139, 20-85 years, rr = 76%), and 2011 (n = 1,175, 20-93 years, rr = 63%). RESULTS: In functional dyspepsia, the odds of postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60-4.84, mixed-effect regression analysis), whereas a small decrease in epigastric pain syndrome was observed (OR: 0.65, 95% CI: 0.42-1.00). The odds of reporting gastroesophageal reflux disease doubled (OR: 2.02; 95% CI: 1.50-2.73). DISCUSSION: The underlying mechanisms behind the increase in postprandial distress syndrome and gastroesophageal reflux disease remain to be determined.
AB - INTRODUCTION: We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing. METHODS: Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21-79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22-80 years, rr = 87%), 1995 (n = 1,139, 20-85 years, rr = 76%), and 2011 (n = 1,175, 20-93 years, rr = 63%). RESULTS: In functional dyspepsia, the odds of postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60-4.84, mixed-effect regression analysis), whereas a small decrease in epigastric pain syndrome was observed (OR: 0.65, 95% CI: 0.42-1.00). The odds of reporting gastroesophageal reflux disease doubled (OR: 2.02; 95% CI: 1.50-2.73). DISCUSSION: The underlying mechanisms behind the increase in postprandial distress syndrome and gastroesophageal reflux disease remain to be determined.
UR - http://www.scopus.com/inward/record.url?scp=85099325586&partnerID=8YFLogxK
U2 - 10.14309/ajg.0000000000000972
DO - 10.14309/ajg.0000000000000972
M3 - Article
C2 - 33027078
AN - SCOPUS:85099325586
SN - 0002-9270
VL - 116
SP - 210
EP - 213
JO - The American Journal of Gastroenterology
JF - The American Journal of Gastroenterology
IS - 1
ER -