TY - JOUR
T1 - An investigation into the powder release behavior from capsule-based dry powder inhalers
AU - Huynh, B. K.
AU - Chen, Y.
AU - Fletcher, D. F.
AU - Young, P.
AU - Zhu, B.
AU - Traini, D.
PY - 2015/10/3
Y1 - 2015/10/3
N2 - A methodology for studying the deagglomeration performance and emptying behavior of micronized mannitol powder from two commercial capsule-based dry powder inhalers (DPIs), the low- and high-resistance RS01®, is presented. Mathematical modeling played a key role in the interpretation of the powder release behavior from these two DPI systems. Non-linear regression models, which were characterized from the aerosol obscuration versus time profiles obtained from laser diffraction particle sizing data, were used to estimate rate constants for emptying of mannitol powder. The effects of device resistance and associated pressure drops, sampling flow rate, rates of powder emptying, and the presence of capsule on the dispersion characteristics were studied. The presence of a capsule significantly improved the aerosolization performance of mannitol powder from both inhalers, which may be due to the extended powder-air-device interactions within the device. It is important to consider the stochastic nature of movement and physical state of the capsule when assessing the aerosolization mechanisms and dispersion performance from these complex delivery systems. The methodology set out in this study has the capacity to provide a greater level of detail in the study of aerosol plume characteristics from capsule-based DPIs.Copyright 2015 American Association for Aerosol Research
AB - A methodology for studying the deagglomeration performance and emptying behavior of micronized mannitol powder from two commercial capsule-based dry powder inhalers (DPIs), the low- and high-resistance RS01®, is presented. Mathematical modeling played a key role in the interpretation of the powder release behavior from these two DPI systems. Non-linear regression models, which were characterized from the aerosol obscuration versus time profiles obtained from laser diffraction particle sizing data, were used to estimate rate constants for emptying of mannitol powder. The effects of device resistance and associated pressure drops, sampling flow rate, rates of powder emptying, and the presence of capsule on the dispersion characteristics were studied. The presence of a capsule significantly improved the aerosolization performance of mannitol powder from both inhalers, which may be due to the extended powder-air-device interactions within the device. It is important to consider the stochastic nature of movement and physical state of the capsule when assessing the aerosolization mechanisms and dispersion performance from these complex delivery systems. The methodology set out in this study has the capacity to provide a greater level of detail in the study of aerosol plume characteristics from capsule-based DPIs.Copyright 2015 American Association for Aerosol Research
UR - http://www.scopus.com/inward/record.url?scp=84943181520&partnerID=8YFLogxK
U2 - 10.1080/02786826.2015.1082532
DO - 10.1080/02786826.2015.1082532
M3 - Article
AN - SCOPUS:84943181520
SN - 0278-6826
VL - 49
SP - 902
EP - 911
JO - Aerosol Science and Technology
JF - Aerosol Science and Technology
IS - 10
ER -