An investigation of neuronal integrity in severe paediatric traumatic brain injury

Louise Parry; Arthur Shores; Caroline Rae; Allan Kemp; Mary Clare Waugh; Ray Chaseling; Pamela Joy

doi:10.1080/09297040490909279

An investigation of neuronal integrity in severe paediatric traumatic brain injury

Louise Parry^*, Arthur Shores, Caroline Rae, Allan Kemp, Mary Clare Waugh, Ray Chaseling, Pamela Joy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Magnetic Resonance Spectroscopy (MRS) and its association with neuropsychological functioning was examined in the chronic injury phase of paediatric traumatic brain injury (TBI). Fifteen children, aged 10-16 years, with severe TBIs were compared with 15 controls, matched for age and gender. The TBI group was found to have significantly lower levels of N-acetyl aspartate (NAA) and Choline (Cho) in the right frontal lobe and generally displayed reduced performances on neuropsychological tests. A correlation between metabolites and reaction times was also obtained. Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments.

Original language	English
Pages (from-to)	248-261
Number of pages	14
Journal	Child Neuropsychology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1080/09297040490909279
Publication status	Published - Dec 2004

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AU - Rae, Caroline

AU - Kemp, Allan

AU - Waugh, Mary Clare

AU - Chaseling, Ray

AU - Joy, Pamela

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AB - Magnetic Resonance Spectroscopy (MRS) and its association with neuropsychological functioning was examined in the chronic injury phase of paediatric traumatic brain injury (TBI). Fifteen children, aged 10-16 years, with severe TBIs were compared with 15 controls, matched for age and gender. The TBI group was found to have significantly lower levels of N-acetyl aspartate (NAA) and Choline (Cho) in the right frontal lobe and generally displayed reduced performances on neuropsychological tests. A correlation between metabolites and reaction times was also obtained. Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments.

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An investigation of neuronal integrity in severe paediatric traumatic brain injury

Abstract

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