An investigation of perceptual processing in autistic spectrum disorder using mis-tuned harmonics

Veema Lodhia, Jon Brock, Blake Johnson, Jeff Hamm, Michael Hautus

    Research output: Contribution to journalMeeting abstract


    Time-shifted dichotic pitch (DP) elicits Object Related Negativity (ORN; associated with object segregation) and Positive 400 (P400; associated with response formation) components in the auditory event related potential (AERP). Our recent work shows that autistics, when compared to matched controls, do not exhibit the ORN but do exhibit a P400 component, when listening to DP stimuli. The aim of this study was to investigate whether components of interest (ORN and P400) are elicited in the AERP of autistics by mistuned harmonics. Participants were ten 18-to-47-year-old adults with ASD and ten matched controls. A mixture of tuned (0%) and mis-tuned (0.5% & 1.5%) harmonic stimulus types were presented. Both controls and autistic s obtained ORN and P400 components in the AERP. Group differences were only found for the autistics for the N1 and N2 in interactions when the location (left/centre/ right) and level (0%, 0.5%, & 1.5%) of the mis-tuned harmonic were factors. This may reflect timing processing deficits in autism. The findings from this study will expand our knowledge on how the brain systematically organises simultaneous incoming auditory information and allow for greater understanding about perceptual processing in Autism.
    Original languageEnglish
    Pages (from-to)236
    Number of pages1
    JournalClinical EEG and neuroscience
    Issue number3
    Publication statusPublished - 2012
    EventAustralasian Cognitive Neurosciences Conference (21st : 2011) - Sydney
    Duration: 9 Dec 201112 Dec 2011


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