An overview of innovations and industrial solutions in protein microarray technology

Shabarni Gupta, K. P. Manubhai, Vishwesh Kulkarni, Sanjeeva Srivastava*

*Corresponding author for this work

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The complexity involving protein array technology reflects in the fact that instrumentation and data analysis are subject to change depending on the biological question, technical compatibility of instruments and software used in each experiment. Industry has played a pivotal role in establishing standards for future deliberations in sustenance of these technologies in the form of protein array chips, arrayers, scanning devices, and data analysis software. This has enhanced the outreach of protein microarray technology to researchers across the globe. These have encouraged a surge in the adaptation of "nonclassical" approaches such as DNA-based protein arrays, micro-contact printing, label-free protein detection, and algorithms for data analysis. This review provides a unique overview of these industrial solutions available for protein microarray based studies. It aims at assessing the developments in various commercial platforms, thus providing a holistic overview of various modalities, options, and compatibility; summarizing the journey of this powerful high-throughput technology.

Original languageEnglish
Pages (from-to)1297-1308
Number of pages12
JournalProteomics
Volume16
Issue number8
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • arrayers
  • data analysis software
  • industry
  • protein microarrays
  • scanners

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