An overview on fast disintegrating sublingual tablets

Manisha Singh, Nitin Chitranshi, Ajay Pal Singh, Vandana Arora, Abdul Wadood Siddiqi

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

The demand of fast disintegrating tablets has been growing during the last decade, due to the characteristics of fast disintegrating sublingual tablets for the potential emergency treatment. In terms of permeability, the sublingual area of the oral cavity (i.e, the floor of the mouth) is more permeable than the buccal (cheek) area, which in turn is more permeable than the palatal (roof) of the mouth. Drug delivery through the oral mucous membrane is considered to be a promising alternative to the oral route. Fast disintegrating sublingual tablets may lead to significant improvements over current treatment options for specific patient group, for instance pediatric and geriatric patients. This review highlights the mechanism of sublingual absorption, factors affecting sublingual absorption, formulation techniques, types of sublingual tablets, advantages, evaluation parameters and commercially available sublingual dosage forms.

LanguageEnglish
Pages407-417
Number of pages11
JournalInternational Journal of Drug Delivery
Volume4
Issue number4
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Tablets
Cheek
Mouth
Mouth Floor
Emergency Treatment
Dosage Forms
Geriatrics
Permeability
Mucous Membrane
Pediatrics
Pharmaceutical Preparations
Oral Mucosal Absorption
Therapeutics

Keywords

  • Angina
  • Dysphagia
  • Improved bioavailability
  • Sublingual delivery
  • Technique

Cite this

Singh, M., Chitranshi, N., Singh, A. P., Arora, V., & Siddiqi, A. W. (2012). An overview on fast disintegrating sublingual tablets. International Journal of Drug Delivery, 4(4), 407-417.
Singh, Manisha ; Chitranshi, Nitin ; Singh, Ajay Pal ; Arora, Vandana ; Siddiqi, Abdul Wadood. / An overview on fast disintegrating sublingual tablets. In: International Journal of Drug Delivery. 2012 ; Vol. 4, No. 4. pp. 407-417.
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Singh, M, Chitranshi, N, Singh, AP, Arora, V & Siddiqi, AW 2012, 'An overview on fast disintegrating sublingual tablets', International Journal of Drug Delivery, vol. 4, no. 4, pp. 407-417.

An overview on fast disintegrating sublingual tablets. / Singh, Manisha; Chitranshi, Nitin; Singh, Ajay Pal; Arora, Vandana; Siddiqi, Abdul Wadood.

In: International Journal of Drug Delivery, Vol. 4, No. 4, 2012, p. 407-417.

Research output: Contribution to journalReview articleResearchpeer-review

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