An overview on fast disintegrating sublingual tablets

Manisha Singh, Nitin Chitranshi*, Ajay Pal Singh, Vandana Arora, Abdul Wadood Siddiqi

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The demand of fast disintegrating tablets has been growing during the last decade, due to the characteristics of fast disintegrating sublingual tablets for the potential emergency treatment. In terms of permeability, the sublingual area of the oral cavity (i.e, the floor of the mouth) is more permeable than the buccal (cheek) area, which in turn is more permeable than the palatal (roof) of the mouth. Drug delivery through the oral mucous membrane is considered to be a promising alternative to the oral route. Fast disintegrating sublingual tablets may lead to significant improvements over current treatment options for specific patient group, for instance pediatric and geriatric patients. This review highlights the mechanism of sublingual absorption, factors affecting sublingual absorption, formulation techniques, types of sublingual tablets, advantages, evaluation parameters and commercially available sublingual dosage forms.

Original languageEnglish
Pages (from-to)407-417
Number of pages11
JournalInternational Journal of Drug Delivery
Volume4
Issue number4
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Angina
  • Dysphagia
  • Improved bioavailability
  • Sublingual delivery
  • Technique

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  • Cite this

    Singh, M., Chitranshi, N., Singh, A. P., Arora, V., & Siddiqi, A. W. (2012). An overview on fast disintegrating sublingual tablets. International Journal of Drug Delivery, 4(4), 407-417.