An overview on vitamin B12 and dementia with behavioral and executive disturbances

Carlo Blundo*, Carmela Gerace, Monica Ricci

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    1 Citation (Scopus)


    Vitamin B12 deficiency can be associated with neurological impairments and mental changes. This chapter discusses the role of vitamin B12 deficiency in the development of various neuropsychiatric symptoms such as delirium, mood disorders, psychosis, and Alzheimer's dementia. In addition, there are cases published in the literature of patients with vitamin B12 deficiency who present with frontotemporal dementia-like behavioral and dysexecutive symptoms and are reversible after treatment with vitamin B12. These mental changes may be attributed to a frontal-subcortical dysfunction secondary to different functional and structural brain damages induced by vitamin B12, folate, or homocysteine abnormal status. Further studies are needed to better identify the clinical profile of such reversible forms of dementia and the role of vitamin B12 in the underlying pathophysiological mechanisms.

    Original languageEnglish
    Title of host publicationDiet and Nutrition in Dementia and Cognitive Decline
    EditorsColin R. Martin, Victor R. Preedy
    Place of PublicationLondon
    PublisherAcademic Press
    Number of pages14
    ISBN (Electronic)9780124079397
    ISBN (Print)9780124078246
    Publication statusPublished - 2015


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