An oxygen consuming phantom for simulating oxygen perfusion in tissue using ¹⁹F MRI oximetry

Steven H. Baete, Yves De Deene

Research output: Contribution to conferenceAbstract

Abstract

Tumor hypoxia is well known to reduce cancer treatment efficacy. ¹⁹F MRI oximetry can be used to map oxygen concentrations in hypoxic tissue. However, validation of pO2-measurements in vivo is difficult. In this study, an oxygen consuming phantom simulating oxygen perfusion in tissue is presented. The phantom consists of a hemodialysis filter of which the outer compartment is filled with a gel containing viable yeast cells. pO₂-images reveal oxygen consumption by the yeast after injection of a bolus of oxygen rich hexafluorobenzene in the fibers of the hemodialysis filter. The phantom can be used for validation of ¹⁹F MRI oximetry.
Original languageEnglish
Pages832
Number of pages1
Publication statusPublished - 2009
EventAnnual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009) - Hawaii, USA
Duration: 18 Apr 200924 Apr 2009

Conference

ConferenceAnnual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009)
CityHawaii, USA
Period18/04/0924/04/09

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    Baete, S. H., & De Deene, Y. (2009). An oxygen consuming phantom for simulating oxygen perfusion in tissue using ¹⁹F MRI oximetry. 832. Abstract from Annual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009), Hawaii, USA, .