Tumor hypoxia is well known to reduce cancer treatment efficacy. ¹⁹F MRI oximetry can be used to map oxygen concentrations in hypoxic tissue. However, validation of pO2-measurements in vivo is difficult. In this study, an oxygen consuming phantom simulating oxygen perfusion in tissue is presented. The phantom consists of a hemodialysis filter of which the outer compartment is filled with a gel containing viable yeast cells. pO₂-images reveal oxygen consumption by the yeast after injection of a bolus of oxygen rich hexafluorobenzene in the fibers of the hemodialysis filter. The phantom can be used for validation of ¹⁹F MRI oximetry.
|Number of pages||1|
|Publication status||Published - 2009|
|Event||Annual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009) - Hawaii, USA|
Duration: 18 Apr 2009 → 24 Apr 2009
|Conference||Annual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009)|
|Period||18/04/09 → 24/04/09|