Abstract
Tumor hypoxia is well known to reduce cancer treatment efficacy. ¹⁹F MRI oximetry can be used to map oxygen concentrations in hypoxic tissue. However, validation of pO2-measurements in vivo is difficult. In this study, an oxygen consuming phantom simulating oxygen perfusion in tissue is presented. The phantom consists of a hemodialysis filter of which the outer compartment is filled with a gel containing viable yeast cells. pO₂-images reveal oxygen consumption by the yeast after injection of a bolus of oxygen rich hexafluorobenzene in the fibers of the hemodialysis filter. The phantom can be used for validation of ¹⁹F MRI oximetry.
| Original language | English |
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| Pages | 832 |
| Number of pages | 1 |
| Publication status | Published - 2009 |
| Event | Annual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009) - Hawaii, USA Duration: 18 Apr 2009 → 24 Apr 2009 |
Conference
| Conference | Annual Meeting of the International Society for Magnetic Resonance in Medicine (17th : 2009) |
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| City | Hawaii, USA |
| Period | 18/04/09 → 24/04/09 |