An update on the current genomic landscape of breast implant-associated anaplastic large cell lymphoma

Sean Harrop; Neha Mehta-Shah; Criselle Dsouza; Ella Thompson; Anand Deva; Henry Miles Prince

doi:10.3390/cancers13194921

An update on the current genomic landscape of breast implant-associated anaplastic large cell lymphoma

Sean Harrop^*, Neha Mehta-Shah, Criselle Dsouza, Ella Thompson, Anand Deva, Henry Miles Prince

^*Corresponding author for this work

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Abstract

Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely can present with disseminated disease. Recent series characterising the genomic landscape of BIA-ALCL have led to insights into the mechanisms of lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as a likely key component while, more recently, aberrancies in epigenetic regulators have been reported. This review describes the genomic characterisation reported to date and the insight these findings have provided into this rare entity.

Original language	English
Article number	4921
Pages (from-to)	1-9
Number of pages	9
Journal	Cancers
Volume	13
Issue number	19
DOIs	https://doi.org/10.3390/cancers13194921
Publication status	Published - 1 Oct 2021

Bibliographical note

Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Breast implants
Epigenetic
JAK/STAT

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10.3390/cancers13194921Licence: CC BY

Publisher version (open access)Final published version, 843 KBLicence: CC BY

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abstract = "Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely can present with disseminated disease. Recent series characterising the genomic landscape of BIA-ALCL have led to insights into the mechanisms of lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as a likely key component while, more recently, aberrancies in epigenetic regulators have been reported. This review describes the genomic characterisation reported to date and the insight these findings have provided into this rare entity.",

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AU - Deva, Anand

AU - Prince, Henry Miles

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AB - Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely can present with disseminated disease. Recent series characterising the genomic landscape of BIA-ALCL have led to insights into the mechanisms of lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as a likely key component while, more recently, aberrancies in epigenetic regulators have been reported. This review describes the genomic characterisation reported to date and the insight these findings have provided into this rare entity.

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An update on the current genomic landscape of breast implant-associated anaplastic large cell lymphoma

Abstract

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