Analysis methods for measuring fNIRS responses generated by a block-design paradigm

Robert Luke, Eric Larson, Maureen J. Shader, Hamish Innes-Brown, Lindsey Van Yper, Adrian K. C. Lee, Paul F. Sowman, David McAlpine

    Research output: Contribution to journalArticle

    Abstract

    Significance fNIRS is an increasingly popular tool in auditory research, but the range of analysis procedures employed across studies complicates interpretation of data.

    Aim To assess the impact of different analysis procedures on the morphology, detection, and lateralization of auditory responses in fNIRS. Specifically, whether averaging or GLM-based analyses generate different experimental conclusions, when applied to a block-protocol design. The impact of parameter selection of GLMs on detecting auditory-evoked responses was also quantified.

    Approach 17 listeners were exposed to three commonly employed auditory stimuli: noise, speech, and silence. A block design was employed, comprising sounds of 5-s duration, and 10–20 s silent intervals.

    Results Both analysis procedures generated similar response morphologies and amplitude estimates, and both also indicated responses to speech to be significantly greater than to noise and silence. Neither approach indicated a significant effect of brain hemisphere on responses to speech. Methods to correct for systemic hemodynamic responses using short channels improved detection at the individual level.

    Conclusions Consistent with theoretical considerations, simulations, and other experimental domains, GLM and averaging analyses generate the same group-level experimental conclusions. We release this dataset publicly for use in future development and optimization of algorithms.
    Original languageEnglish
    JournalbioRxiv
    DOIs
    Publication statusSubmitted - 22 Dec 2020

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