Analysis of biological reference materials, prepared by microwave dissolution, using inductively coupled plasma mass spectrometry

James K. Friel*, Craig S. Skinner, Simon E. Jackson, Henry P. Longerich

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    111 Citations (Scopus)

    Abstract

    A procedure has been developed for the analysis of biological materials by inductively coupled plasma mass spectrometry (ICP-MS). Fast, efficient and complete sample digestion is achieved by a combined microwave - nitric acid/open beaker - nitric acid - hydrogen peroxide procedure. The ICP-MS analysis is performed with an on-line five-element internal standard to correct for matrix and instrumental drift effects. Results are presented for 24 elements in three biological reference materials (National Institute of Standards and Technology Standard Reference Materials 5277a Liver and 1566 Oyster and International Atomic Energy Agency Certified Reference Material H4 Animal Muscle). For all elements significantly above the detection limit and reagent blank concentrations, good agreement exists between ICP-MS and certified values.

    Original languageEnglish
    Pages (from-to)269-273
    Number of pages5
    JournalThe Analyst
    Volume115
    Issue number3
    Publication statusPublished - 1990

    Keywords

    • Biological tissue
    • Inductively coupled plasma mass spectrometry
    • Microwave digestion

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