Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.
- Antifungal activity
- Data condensation
Hutchinson, T. P. (2004). Analysis of datasets showing which compounds kill which organisms: inferring two systems. European Journal of Medicinal Chemistry, 39(1), 107-111. https://doi.org/10.1016/j.ejmech.2003.11.006