Analysis of datasets showing which compounds kill which organisms: inferring two systems

T. Paul Hutchinson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.
    Original languageEnglish
    Pages (from-to)107-111
    Number of pages5
    JournalEuropean Journal of Medicinal Chemistry
    Volume39
    Issue number1
    DOIs
    Publication statusPublished - 2004

    Keywords

    • 2,4-Dihydroxythiobenzanilides
    • Antifungal activity
    • Data condensation
    • Dermatophytes

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