Analysis of datasets showing which compounds kill which organisms: inferring two systems

T. Paul Hutchinson

doi:10.1016/j.ejmech.2003.11.006

Analysis of datasets showing which compounds kill which organisms: inferring two systems

T. Paul Hutchinson

Research output: Contribution to journal › Article › peer-review

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Abstract

Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2003.11.006
Publication status	Published - 2004

Keywords

2,4-Dihydroxythiobenzanilides
Antifungal activity
Data condensation
Dermatophytes

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10.1016/j.ejmech.2003.11.006

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title = "Analysis of datasets showing which compounds kill which organisms: inferring two systems",

abstract = "Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.",

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AB - Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.

KW - 2,4-Dihydroxythiobenzanilides

KW - Antifungal activity

KW - Data condensation

KW - Dermatophytes

UR - https://www.scopus.com/pages/publications/1342321915

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JO - European Journal of Medicinal Chemistry

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IS - 1

ER -

Analysis of datasets showing which compounds kill which organisms: inferring two systems

Abstract

Keywords

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