Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe

Chinthaka P. Gooneratne, Adam Kurnicki, Sotoshi Yamada, Subhas C. Mukhopadhyay, Jürgen Kosel

Research output: Contribution to journalArticle

12 Citations (Scopus)
14 Downloads (Pure)

Abstract

Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42°C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe.

Original languageEnglish
Article numbere81227
Pages (from-to)1-14
Number of pages14
JournalPLoS ONE
Volume8
Issue number11
DOIs
Publication statusPublished - 29 Nov 2013
Externally publishedYes

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