Analytical SERS for liquid biopsy biomarkers detection

Anastasiia Tukova; Wei Zhang; Alison Rodger; Yuling Wang

doi:10.1007/978-981-97-5818-0_19

Analytical SERS for liquid biopsy biomarkers detection

Anastasiia Tukova, Wei Zhang, Alison Rodger, Yuling Wang^*

^*Corresponding author for this work

School of Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Considerable research effort has been dedicated to devising analytical techniques for cancer diagnosis and monitoring of treatment progress and prognosis by tracking a range of cancer biomarkers including circulating tumour cells (CTCs), small extracellular vehicles (sEVs), circulating nucleic acids, RNA and DNA, and specific proteins, primarily in blood. These analyses are collectively referred to as liquid biopsies. Due to the low abundance of such biomarkers in the blood there is an urgent need to establish swift and dependable assays for gauging their presence and quantity within patient samples. Surface-enhanced Raman scattering (SERS) has garnered substantial attention for this purpose owing to its unique advantages of high sensitivity, specificity, multiplexing capability, and photostability. Therefore, SERS has been widely used in many applications, among which analytical SERS has been the focus in recent years. In this book chapter, we provide an overview of recent developments (within the last 5 years) in analytical SERS for liquid biopsy biomarkers detection. We also provide our insights into the forthcoming challenges in the realm of SERS applications for biomarkers detection towards cancer diagnosis.

Original language	English
Title of host publication	Surface and Tip-Enhanced Raman Scattering Spectroscopy
Subtitle of host publication	Bridging Theory and Applications
Editors	Marek Procházka, Janina Kneipp, Bing Zhao, Yukihiro Ozaki
Place of Publication	Singapore
Publisher	Springer, Springer Nature
Chapter	19
Pages	567-607
Number of pages	41
ISBN (Electronic)	9789819758180
ISBN (Print)	9789819758173
DOIs	https://doi.org/10.1007/978-981-97-5818-0_19
Publication status	Published - 2024

Keywords

SERS
Plasmonic nanostructure
Nanotags
Biosensing
Biomarker

Access to Document

10.1007/978-981-97-5818-0_19

Cite this

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title = "Analytical SERS for liquid biopsy biomarkers detection",

abstract = "Considerable research effort has been dedicated to devising analytical techniques for cancer diagnosis and monitoring of treatment progress and prognosis by tracking a range of cancer biomarkers including circulating tumour cells (CTCs), small extracellular vehicles (sEVs), circulating nucleic acids, RNA and DNA, and specific proteins, primarily in blood. These analyses are collectively referred to as liquid biopsies. Due to the low abundance of such biomarkers in the blood there is an urgent need to establish swift and dependable assays for gauging their presence and quantity within patient samples. Surface-enhanced Raman scattering (SERS) has garnered substantial attention for this purpose owing to its unique advantages of high sensitivity, specificity, multiplexing capability, and photostability. Therefore, SERS has been widely used in many applications, among which analytical SERS has been the focus in recent years. In this book chapter, we provide an overview of recent developments (within the last 5 years) in analytical SERS for liquid biopsy biomarkers detection. We also provide our insights into the forthcoming challenges in the realm of SERS applications for biomarkers detection towards cancer diagnosis.",

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Analytical SERS for liquid biopsy biomarkers detection. / Tukova, Anastasiia ; Zhang, Wei ; Rodger, Alison et al.
Surface and Tip-Enhanced Raman Scattering Spectroscopy: Bridging Theory and Applications. ed. / Marek Procházka; Janina Kneipp; Bing Zhao; Yukihiro Ozaki. Singapore: Springer, Springer Nature, 2024. p. 567-607.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Analytical SERS for liquid biopsy biomarkers detection

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AU - Zhang, Wei

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AU - Wang, Yuling

PY - 2024

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N2 - Considerable research effort has been dedicated to devising analytical techniques for cancer diagnosis and monitoring of treatment progress and prognosis by tracking a range of cancer biomarkers including circulating tumour cells (CTCs), small extracellular vehicles (sEVs), circulating nucleic acids, RNA and DNA, and specific proteins, primarily in blood. These analyses are collectively referred to as liquid biopsies. Due to the low abundance of such biomarkers in the blood there is an urgent need to establish swift and dependable assays for gauging their presence and quantity within patient samples. Surface-enhanced Raman scattering (SERS) has garnered substantial attention for this purpose owing to its unique advantages of high sensitivity, specificity, multiplexing capability, and photostability. Therefore, SERS has been widely used in many applications, among which analytical SERS has been the focus in recent years. In this book chapter, we provide an overview of recent developments (within the last 5 years) in analytical SERS for liquid biopsy biomarkers detection. We also provide our insights into the forthcoming challenges in the realm of SERS applications for biomarkers detection towards cancer diagnosis.

AB - Considerable research effort has been dedicated to devising analytical techniques for cancer diagnosis and monitoring of treatment progress and prognosis by tracking a range of cancer biomarkers including circulating tumour cells (CTCs), small extracellular vehicles (sEVs), circulating nucleic acids, RNA and DNA, and specific proteins, primarily in blood. These analyses are collectively referred to as liquid biopsies. Due to the low abundance of such biomarkers in the blood there is an urgent need to establish swift and dependable assays for gauging their presence and quantity within patient samples. Surface-enhanced Raman scattering (SERS) has garnered substantial attention for this purpose owing to its unique advantages of high sensitivity, specificity, multiplexing capability, and photostability. Therefore, SERS has been widely used in many applications, among which analytical SERS has been the focus in recent years. In this book chapter, we provide an overview of recent developments (within the last 5 years) in analytical SERS for liquid biopsy biomarkers detection. We also provide our insights into the forthcoming challenges in the realm of SERS applications for biomarkers detection towards cancer diagnosis.

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KW - Nanotags

KW - Biosensing

KW - Biomarker

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ER -

Analytical SERS for liquid biopsy biomarkers detection

Abstract

Keywords

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DP22: Next-generation epigenetic analysis: direct reading of DNA methylation

FAAB: ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB)

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Analytical SERS for liquid biopsy biomarkers detection

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

DP22: Next-generation epigenetic analysis: direct reading of DNA methylation

FAAB: ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB)

Cite this