Analyzing the effect of resolution of network nodes on the resting state functional connectivity maps of schizophrenic human brains

Functional connectivity (FC) mapping from resting-state functional magnetic resonance imaging (rsfMRI) data is a widely used technique to characterize the brain abnormalities in mental health disorders. Using atlases for brain parcellation is an important intermediate step in calculation of FC maps. Atlases with varying resolution (number of nodes in an atlas) have been deployed by researchers to study the abnormal brain functions in Schizophrenia. In this work, we compared the variations in FC maps of Schizophrenic brains obtained from three different atlases: AAL atlas (2002), Dosenbach atlas (2010), and the Brainnetome atlas (2016). To evaluate the atlas-dependent variations in FC maps, we relied on the capability of the features of FC maps in accurately classifying a given data into healthy or Schizophrenia group. Our results indicate that the high-resolution Dosenbach and Brainnetome atlases perform better than AAL atlas in terms of the accuracy, sensitivity and specificity of the SVM classifier.