Androgen deprivation in prostate cancer

benefits of home-based resistance training

Teresa Lam*, Birinder Cheema, Amy Hayden, Stephen R. Lord, Howard Gurney, Shivanjini Gounden, Navneeta Reddy, Haleh Shahidipour, Scott Read, Glenn Stone, Mark McLean, Vita Birzniece

*Corresponding author for this work

Research output: Contribution to journalArticle


Introduction: Androgen deprivation therapy (ADT) has detrimental effects on body composition, metabolic health, physical functioning, bone mineral density (BMD) and health-related quality of life (HRQOL) in men with prostate cancer. We investigated whether a 12-month home-based progressive resistance training (PRT) programme, instituted at the start of ADT, could prevent these adverse effects. Methods: Twenty-five patients scheduled to receive at least 12 months of ADT were randomly assigned to either usual care (UC) (n = 12) or PRT (n = 13) starting immediately after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), BMD, physical function, insulin sensitivity and HRQOL were measured at 6 weeks and 6 and 12 months. Data were analysed by a linear mixed model. Results: ADT had a negative impact on body composition, BMD, physical function, glucose metabolism and HRQOL. At 12 months, the PRT group had greater reductions in BCM by − 1.9 ± 0.8 % (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0 % (p = 0.002), compared to the UC group. HRQOL domains were maintained or improved in the PRT versus UC group at 6 weeks (general health, p = 0.04), 6 months (vitality, p = 0.02; social functioning, p = 0.03) and 12 months (mental health, p = 0.01; vitality, p = 0.02). A significant increase in the Matsuda Index in the PRT versus UC group was noted at 6 weeks (p = 0.009) but this difference was not maintained at subsequent timepoints. Between-group differences favouring the PRT group were also noted for physical activity levels (step count) (p = 0.02). No differences in measures of BMD or physical function were detected at any time point. Conclusion: A home-based PRT programme instituted at the start of ADT may counteract detrimental changes in body composition, improve physical activity and mental health over 12 months. Trial registration: Australian and New Zealand Clinical Trials Registry, ACTRN12616001311448

Original languageEnglish
Article number59
Pages (from-to)1-12
Number of pages12
JournalSports Medicine - Open
Issue number1
Publication statusPublished - 14 Dec 2020
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Adverse effects
  • Androgen deprivation therapy
  • Progressive resistance training
  • Prostate cancer

Fingerprint Dive into the research topics of 'Androgen deprivation in prostate cancer: benefits of home-based resistance training'. Together they form a unique fingerprint.

Cite this